Fattori prognostici Sono stati proposti diversi fattori di prognosi, potenzialmente in grado di predire i risultati terapeutici della LAP. Concentrazioni farmacologiche di ATRA sono in grado di indurre una modifica della conformazione dei complessi multifunzionali connessi a PML-RARalpha, con il rilascio di specifici corepressori. Nel complesso, il trattamento della LAP include le fasi di induzione, consolidamento e mantenimento. Uno dei quesiti ancora discussi concerne il tipo di chemioterapia da associare ad ATRA.
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Faeshakar Because of the acuteness of onset compared to other leukemias, early death is comparatively more common. Prospective validation of the Promiielocitica Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. A previously uncharacterized gene, PML, is fused to the retinoic acid receptor alpha gene in acute promyelocytic leukaemia.
Recurrent differentiation syndrome or septic shock? Mastocytoma Mast cell leukemia Mast cell sarcoma Systemic mastocytosis. From the molecular model to the impact on prognosis: an overview on acute promyelocytic leukemia Remission with arsenic trioxide has been reported. Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: All-trans-retinoic acid in acute promyelocytic leukemia. On rare occasions, a cryptic translocation may occur which cannot be detected by cytogenetic testing; on these occasions PCR testing is essential to confirm the diagnosis.
Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. Archived from the original PDF on Early death rate in acute promyelocytic leukemia remains high despite all-trans retinoic acid. The molecular pathogenesis of acute promyelocytic leukaemia: International Society on Thrombosis and Haemostasis score for overt disseminated intravascular coagulation predicts organ dysfunction and fatality in sepsis patients.
Retrieved 15 January Potential role of interleukin-1 as the trigger for diffuse intravascular coagulation in aneima nonlymphoblastic leukemia. Braz J Med Biol Res. A maior causa de morte foi a hemorragia grave, especialmente no sistema nervoso central SNC. Arsenic trioxide in the treatment of acute promyelocytic leukemia. Prkmielocitica and allogeneic stem-cell transplantation as salvage treatment of acute group.
Proteolysis of von Willebrand factor is decreased in acute promyelocytic leukaemia by treatment with all-trans-retinoic acid. ATRA therapy is associated with the unique side effect of retinoic acid syndrome. Juvenile myelomonocytic leukemia Chronic myelomonocytic leukemia.
British Journal of Haematology. CD34 and CD2 expression in acute promyelocytic leukemia. Acute promyelocytic leukemia A model of molecular target based therapy. Treatment of acute promyelocytic leukemia. Acute promyelocytic leukemia-associated thrombosis. Who Classification of tumours of haematopoietic and lymphoid tissues. Incidence is higher among individuals of Latin American or South European origin. All-trans retinoic acid upregulates thrombomodulin and downregulates tissue-factor expression in acute promyelocytic leukemia cells: A new variant t 6;15;17 q25;q22;q21 in acute promyelocytic leukemia: Targeting FLT3 for the treatment of leukemia.
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Tojarn Is cytarabine useful in the treatment of acute promyelocytic leukemia? Holland-Frei Cancer Medicine 5th ed. Risk factors for early death due to hemorrhage include delayed snemia, late treatment initiation, and high white blood cell count on admission. On rare occasions, a cryptic translocation may occur which cannot be detected by cytogenetic testing; on these occasions PCR testing is essential to confirm the diagnosis. Management of acute promyelocytic leukemia: Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disesase. The slightly high mortality rates, especially early mortality, motivate studies to understand this pathology in the Brazilian context.
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