BETALACTAMASAS DE ESPECTRO EXTENDIDO PDF

Penicilinasas no incluidas en los otros grupos. La clase B necesita zinc. En se describieron las cefotaximasas o CTX-M-asas. Se encuentran fundamentalmente en cepas de Salmonella enterica serovar thyphimurium y E. Se desconoce la prevalencia real de las BLEE, siendo probablemente subestimadas las cifras que habitualmente se comunican.

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Penicilinasas no incluidas en los otros grupos. La clase B necesita zinc. En se describieron las cefotaximasas o CTX-M-asas. Se encuentran fundamentalmente en cepas de Salmonella enterica serovar thyphimurium y E.

Se desconoce la prevalencia real de las BLEE, siendo probablemente subestimadas las cifras que habitualmente se comunican. Entre las distintas regiones hay marcadas diferencias. Actualmente, el aislamiento de cepas de E.

Menor peso global tienen de momento otras enterobacterias, como Citrobacter, Enterobacter, Pseudomonas, Serratia, Salmonella o Morganella. Se han comunicado brotes polimicrobianos. Las muestras con K. Las cepas de K. En las UCI la frecuencia media de K. Estos falsos negativos iniciales se han comunicado con cierta frecuencia. Conviene tener en cuenta que no en todos los centros se detectan BLEE, por diferentes motivos. Las cepas productoras de BLEE son multirresistentes.

Pueden considerarse en infecciones leves. Esta cifra se ha incrementado respecto al informe de [60]. Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens. Infection ; Antimicrob Agents Chemother ; The structure of beta-lactamases.

Disponible en: [ Lahey. Cefotaximases CTX-M-ases , an expanding family of extended-spectrum beta-lactamases. Can J Microbiol ; Antimicrobial resistance amongst Klebsiella spp.

J Antimicrob Chemother ; Extended-spectrum beta-lactamases: the European experience. Curr Opin Infect Dis ; Diagn Microbiol Infect Dis ; Cloning and sequence of the gene encoding a novel cefotaxime-hydrolyzing beta-lactamase CTX-M-9 from Escherichia coli.

J Clin Microbiol ; An outbreak of hospital-acquired Klebsiella pneumoniae bacteraemia, including strains producing extended-spectrum beta-lactamase. J Hosp Infect ; Risk factors for faecal carriage of Klebsiella pneumoniae producing extended spectrum beta-lactamase ESBL-KP in the intensive care unit. Hosp Infect ; Outbreak of multiply resistant Enterobacteriaceae in an intensive care unit: epidemiology and risk factors for acquisition. Clin Infect Dis , Beta-lactamases involved in resistance to broad-spectrum cephalosporins in Escherichia coli and Klebsiella spp.

Microb Drug Resist ; 9: Enferm Infecc Microbiol Clin ; Outbreak of a multiresistant Klebsiella pneumoniae strain in an intensive care unit: antibiotic use as risk factor for colonization and infection.

Clin Infect Dis ; Co-carriage rates of vancomycin-resistant Enterococcus and extended-spectrum beta-lactamase-producing bacteria among a cohort of intensive care unit patients: implications for an active surveillance program. Infect Control Hosp Epidemiol ; Hands as a route of transmission for Klebsiella species. BMJ ; 2: Outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit linked to artificial nails.

Antibiotic resistance and production of extended-spectrum beta-lactamases amongst Klebsiella spp. Performance standards for antimicrobial susceptibility testing.

Wayne PA. Outcome of cephalosporin treatment for serious infections due to apparently susceptible organisms producing extended-spectrum beta-lactamases: implications for the clinical microbiology laboratory. Antimicrobial activity and spectrum investigation of eight broad-spectrum beta-lactam drugs: a surveillance trial in medical centers in the United States. Cefepime Study Group. In vitro evaluation of cefepime and other broad-spectrum beta-lactams in eight medical centers in Thailand.

Sustained activity and spectrum of selected extended-spectrum beta-lactams carbapenems and cefepime against Enterobacter spp. Int J Antimicrob Agents ; Cefepime, piperacillin-tazobactam, and the inoculum effect in tests with extended-spectrum beta-lactamase-producing Enterobacteriaceae.

Pharmacokinetics-pharmacodynamics of cefepime and piperacillin-tazobactam against Escherichia coli and Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases: report from the ARREST program.

Pharmacotherapy ; Bactericidal activity of three beta-lactams alone or in combination with a beta-lactamase inhibitor and two aminoglycosides against Klebsiella pneumoniae harboring extended-spectrum beta-lactamases.

Clin Microbiol Infect ; 4: Post-antibiotic and post-beta-lactamase inhibitor effects of ceftazidime plus sulbactam on extended-spectrum beta-lactamase-producing Gram-negative bacteria. Antibiotic resistance in invasive isolates of Escherichia coli in 27 Spanish hospitals participating in the European Antimicrobial Resistance Surveillance System Drugs ; In vitro activity of parenteral beta-lactams, levofloxacin and tobramycin alone or in combination against extended-spectrum beta-lactamase producing Klebsiella pneumoniae.

In vitro killing of parenteral beta-lactams against standard and high inocula of extended-spectrum beta-lactamase and non-esbl producing Klebsiella pneumoniae. In vitro activity of gatifloxacin alone and in combination with cefepime, meropenem, piperacillin and gentamicin against multidrug-resistant organisms.

Emergence and rapid spread of carbapenem resistance during a large and sustained hospital outbreak of multiresistant Acinetobacter baumannii. Comparative activities of doripenem versus isolates, mutants, and transconjugants of Enterobacteriaceae and Acinetobacter spp.

Effect of different beta-lactams in combination with beta-lactamase inhibitors in the presence or absence of tobramycin against some Enterobacteriaceae producing extended-spectrum beta-lactamases. Chemotherapy ; Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella. JAMA ;

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BETALACTAMASAS DE ESPECTRO EXTENDIDO

Cir Cir. Antecedentes: La gangrena de Fournier GF es una fascitis necrotizante que pone en peligro la vida del paciente. Los valores cualitativos medidos se expresaron como frecuencia y porcentaje, y se compararon con la prueba de ji al cuadrado y la prueba de Fisher. Resultados: Los pacientes que murieron presentaban con mayor frecuencia cultivos de orina y herida positivos para Escherichia coli productora de betalactamasas de espectro extendido BLEE : orina, sobrevivientes

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